PhD in Scienze della Vita 38° cycle, Sapienza University of Rome
PhD in Scienze della Vita 38° cycle, Sapienza University of Rome Title of the project: Dissecting the Nrf2 pathway and its impact on the redox changes and the inflammatory response upon coronavirus and influenza virus infections Respiratory viruses use different strategies to manipulate host cell machinery to their advantage including the modulation of redox state. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key player in maintaining the intracellular redox state homeostasis. In presence of oxidative stress, it transcribes for genes involved in the antioxidant pathways, but also in regulating cell metabolism and inflammatory response. We have already demonstrated [...]