Hedgehog/Gli signaling as a mediator of the pro-tumorigenic effect of Fusobacterium nucleatum in colorectal cancer stem cells

One 12-month research fellowship at Università Cattolica School of Medicine of Rome

 

The project will investigate the role of the morphogenetic pathway Hedgehog/Gli in mediating the interaction between Fusobacterium nucleatum, an oral pathogen alleged to colonize and promote colorectal cancer, and the malignant stem cells (CSC) that initiate this neoplasm. The research, which involves expertise in cell biology (CSC isolation and culture), Microbiology, and Molecular Biology, will hopefully identify novel molecular targets for preventing and treating this life-threatening disease.  Activities will be carried out in a highly stimulating, international scientific environment with direct access to the state-of-the-art facilities and cutting-edge technologies of the Gemelli Science and Technology Park  (visit https://gemellihospital.com/science-and-research/gstep/)

• Applications are invited for one 12-month research fellowship (renewable for a further six months).
• Applicants are expected to hold at least a Master’s Degree in the field of biomedicine and have proven expertise in the basic techniques of cellular and molecular biology.
• Ph.D. and reference letters are welcome.

 

For more information, please contact Prof. Giovambattista Pani, MD, PhD:

Giovambattista.pani@unicatt.it

https://docenti.unicatt.it/ppd2/en/docenti/46686/giovambattista-pani/profilo